Endocrine Abstracts

Purpose: MicroRNAs (miRNAs) are a fundamental component of gene regulation mechanisms. Presently, altered miRNA patterns of expression have been documented in different human cancers, and they may explain the distinct behavior of pituitary adenomas (PA) and the differences between subtypes. miR-375 can target among other genes to IGF1 receptor (IGF1R) and participes in reprogramming cancer cell metabolism. The aim of this study was to assess the miR-375 role on pathogenesis of...

Purpose: The 2004 edition of the WHO text ‘Histological typing of endocrine tumors’ classified pituitary adenomas (PA) on the basis of their histological and immunohistochemical characteristics. Recent advances on the knowledge of the molecular patterns of these tumours may allow establishing a molecular classification with higher accuracy and specificity than previous one.Methods: Within the pale of the multicenter Spanish Molecular Registry o...

Purpose: IGF receptor 1 (IGF1R) and epidermal growth factor receptor (EGFR) are receptors tyrosine-kinase (RTK) whose altered signaling are critical factors in development of many types of tumours. These RTK are some of the main targets of the microRNA miR-7. This important tumor supressor miRNA has the ability to inhibit the motility, invasiveness and anchorage-independent growth, suggesting a strong therapeutic potential in many types of cancer. Pituitary adenomas (PA) are a...

Introduction: Sleep disordered breathing (SDB) promotes structural myocardial changes and can trigger cardiac arrhythmias. Acromegalic patients have high prevalence of SDB and GH–IGF1 excess is related to a specific cardiomyopathy characterized by concentric cardiac hypertrophy and diastolic dysfunction. The aim of this study was to assess the relationship between SDB and cardiac dysfunction on acromegalic patients.Material and methods: Observationa...

Introduction: The immunohistochemical characterization of Pit-1, Tpit and SF-1 transcription factors allows the identification of the three adenohypophyseal cell lines and has been incorporated into the latest WHO classification of pituitary adenomas (PA). The aim of the present study was to quantify the protein expression of pituitary-specific transcription factors (TF) by immunohistochemistry (IHC) and to correlate these results with the identification based on hormonal prot...